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Probability??


Question: A man with hemophilia is having a child with a woman that is a recessive carrier for hemophilia. What is the probability that any of their children with suffer from hemophilia?
Answers: 25% chance of having a girl with it, 25% chance of having a boy with it ...50% total chance of having a child with it.

25% chance of having a girl that is a carrier.

25% chance of having a normal boy.

The hemophilia gene is found in the sex chromosomes. The missing arm on the Y chromosome (the chromosome responsible for making a boy) is what corresponds to the affected part of the gene on the X chromosome. A boy child only needs to have one affected X gene to become a hemophyliac, where as a girl needs to have both genes affected.

For a boy child, the dad will give his Y chromosome (which does not carry the gene). The mom has one affected and one not affected gene, so the boy will have a 50% chance of accquiring it.

For a girl child, the dad will give his affected X chromosome, so a girl child will always have atleast one affected gene, meaning at best she would be a carrier. Whether she would be just a carrier or have the disease would depend on whether she got the affected gene or the unaffected gene from her mother.
Man is Hh, same as the Woman (hemophilia only affects woman who are HH, it affects Men even when its Hh i believe).

Therefore the possible combos are (out of 4 children):
HH
Hh (Twice the chance)
hh

In conclusion, if their child was Male it would have a 3 in 4 chance, if the child was female, itd have a 1 in 4 chance.

Be aware the haemophiliacs make it a point not to breed, its an exremely heavy burden to give to a child.


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